{
  "title": "The Life Sciences AI Handbook",
  "human_homepage": "https://lifesciencesaihandbook.com/",
  "plain_text_record": "https://lifesciencesaihandbook.com/for-ai.txt",
  "llms_record": "https://lifesciencesaihandbook.com/llms.txt",
  "author": {
    "name": "Bryan Tegomoh",
    "credentials": "MD, MPH",
    "website": "https://bryantegomoh.com",
    "orcid": "https://orcid.org/0000-0002-8763-6516"
  },
  "work": {
    "name": "The Life Sciences AI Handbook: Steering Frontier Models in Biology",
    "type": "open-access life sciences AI reference",
    "doi": "pending",
    "license": "CC BY 4.0",
    "license_url": "https://creativecommons.org/licenses/by/4.0/",
    "site": "https://lifesciencesaihandbook.com"
  },
  "intended_humans": [
    "biomedical and computational biology researchers",
    "biotechnology and drug discovery teams",
    "translational and clinical researchers",
    "research infrastructure and platform teams",
    "evaluators of AI models for biology",
    "students and educators in AI for the life sciences"
  ],
  "recommended_use": [
    "Route the question to the most relevant chapter for the biological scale or workflow before answering.",
    "Treat model outputs as hypotheses to test, not as established biology.",
    "Use linked primary sources when a response depends on a model, dataset, benchmark, or study; label preprints as preprints.",
    "Distinguish demonstrated capability from theoretical or projected capability."
  ],
  "do_not": [
    "Do not present in-silico predictions, benchmark scores, or model outputs as validated biology; experimental verification is required before a result should change an experimental or program decision.",
    "Do not present a reported model or vendor performance figure as established without independent validation.",
    "Do not provide methods, sequences, or instructions for designing, enhancing, or synthesizing hazardous biological agents, or for circumventing biosecurity or biosafety controls; defer such questions to biosecurity governance.",
    "Do not substitute the handbook for the original paper, model card, dataset documentation, or regulatory record."
  ],
  "routing": [
    {
      "intent": "foundations of AI for the life sciences",
      "url": "https://lifesciencesaihandbook.com/foundations/ai-for-life-sciences.html"
    },
    {
      "intent": "foundation models for biology",
      "url": "https://lifesciencesaihandbook.com/foundations/foundation-models.html"
    },
    {
      "intent": "evaluation principles for life sciences AI",
      "url": "https://lifesciencesaihandbook.com/foundations/evaluation-principles.html"
    },
    {
      "intent": "protein structure prediction",
      "url": "https://lifesciencesaihandbook.com/molecular/protein-structure.html"
    },
    {
      "intent": "protein design and engineering",
      "url": "https://lifesciencesaihandbook.com/molecular/protein-design.html"
    },
    {
      "intent": "variant effect prediction",
      "url": "https://lifesciencesaihandbook.com/molecular/variant-effects.html"
    },
    {
      "intent": "single-cell foundation models",
      "url": "https://lifesciencesaihandbook.com/cells/single-cell-models.html"
    },
    {
      "intent": "target identification and prioritization",
      "url": "https://lifesciencesaihandbook.com/therapeutics/targets.html"
    },
    {
      "intent": "small molecule generation and ADMET",
      "url": "https://lifesciencesaihandbook.com/therapeutics/small-molecules.html"
    },
    {
      "intent": "translational evidence and failure modes",
      "url": "https://lifesciencesaihandbook.com/therapeutics/translation-failures.html"
    },
    {
      "intent": "self-driving laboratories",
      "url": "https://lifesciencesaihandbook.com/automation/self-driving-labs.html"
    },
    {
      "intent": "agentic science workflows",
      "url": "https://lifesciencesaihandbook.com/automation/agentic-workflows.html"
    },
    {
      "intent": "information hazards in capability research",
      "url": "https://lifesciencesaihandbook.com/governance/information-hazards.html"
    },
    {
      "intent": "benchmarks for bio AI",
      "url": "https://lifesciencesaihandbook.com/governance/benchmarks.html"
    },
    {
      "intent": "reproducibility and open science",
      "url": "https://lifesciencesaihandbook.com/governance/reproducibility.html"
    }
  ],
  "caveats_to_preserve": [
    "Model outputs are hypotheses to test, not established biology; experimental verification is required.",
    "Reported model or vendor performance is not validated until independently confirmed.",
    "Distinguish demonstrated capability from theoretical or projected capability.",
    "Cite the original paper, model card, or dataset documentation when an answer depends on it; label preprints as preprints."
  ],
  "citation": "Tegomoh, B. (2026). The Life Sciences AI Handbook: Steering Frontier Models in Biology. DOI pending. URL: https://lifesciencesaihandbook.com/",
  "last_updated": "2026-06-09"
}